Religion is a system through which people reach their gods and goddess or super natural being for the purpose of problem solving, communication or interaction. It includes people’s belief, faith, practices or veneration etc. in any given environment. Health system is the condition of man’s body or mechanism when something is wrong and need to be addressed either with drugs, human experts, medical gadgets, therapy or prayer with faith. There are some health related challenges found in any given environment which may erupt as a result of epidemic, biological trait, type of feeding, malnutrition, environmental hazard, infection or spiritual sickness etc. Some believe in faith clinic alone while some make use of both prayer and drugs or other means of medical help either traditional or scientific. The paper therefore discussed the concept of religion and health system, the role of religion in the reduction of health related challenges. It also examined the challenges of religion and religious leaders in eradication of health problem in Nigeria society and recommends increase in religious faith and adequate treatment from the hospitals and medical-experts when faced with any disease, illness or any form of sickness for quick healing