This study investigated into resilience effects on the self- development of adolescents in secondary schools in Kumba II Sub Division of South West, Cameroon. Focus was on adaptation, locus of control, self-efficacy and persistence and their relationship with self-development. The descriptive survey design was used with a sample of 303 adolescent students. The instrument used for data collection was a self-constructed questionnaire with a reliability of 0.712. Data were analyzed using frequency counts, percentages and Spearman rho test to establish relationships between resilience and self-development. The findings showed a significant and positive relationship between adaptation and self-development (P-value=0.048<0.05). The positive sign of the correlation value (R=0.211) implied that self-development was more likely when adolescents were well adapted in their environment. Findings equally affirmed that there was a significant and positive relationship between locus of control and self-development (P-value=0.000<0.05). The positive sign of the correlation value (R=0.235) implied that self-development was more likely when they adequately control their behavior in their environment. Similarly, the findings equally revealed that there was a significant and positive relationship between self-efficacy and self-development (P-value=0.000<0.05). The positive sign of the correlation value (R=0.311) implied that self-development was more likely when they portray high self-efficacy about their own self. Finally, the findings on persistence revealed that there was a significant and positive relationship between persistence and selfdevelopment (P-value=0.000<0.05). The positive sign of the correlation value (R=0.244) implied that self-development was more likely when they portray high level of persistence in their environment. The findings indicated that resilience therefore has an effect on the self-development of adolescents in secondary schools in Kumba. Based on the findings, some recommendations were made that the government should sensitize adolescents on forums to be resilient because the findings of this study have showed that adolescents are endowed with resilient potentials. Adolescents should be seen as contributors to the welfare of society not passive agents. Seminars, workshops, refresher courses could be organized to educate adolescents on issues that will help deviate their minds from deviant behaviours and juvenile delinquency and to be more engage in activities that can add values in their lives and improve on their self-development.