This paper reviews all the literatures related to Defense Mechanisms and Psycho-immunity individually, based on various articles and books. A framework is provided that determines the correlation between the use of defense mechanisms and Psycho-immunity and does gender play a major role difference in this process. And to improve Psycho-immunity by using some indigenous techniques. The review is structured first, to provide a brief overview. Second, to integrate the literatures of defense mechanisms and psycho-immunity. Third, to describe the literatures of improving psycho-immunity with the help of indigenous techniques. Finally, the research agenda of this review article is to provide suggestions, about the dynamics of behavioral patterns of both the gender as well as their psycho-immunities, and how to improve their psycho-immunity